SBRT affords good local tumor control and higher overall survival rates than other historical controls (best supportive care or sorafenib). High aFP levels were associated with lesser local control, but a higher treatment dose improved local control.

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Especially for patients surviving >1-year, improved tumor control associated with SBRT re-irradiation may mitigate decreased PR-QoL resulting from rSCCHN. These improvements in PR-QoL are magnified throughout the duration of clinical follow-up and transcend all measured domains in a validated PR-QoL assessment tool.

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The current study presents the results of prospective QoLassessment after (chemo)radiation for OPC using the EORTC QLQC30, and QLQ-H&N35-questionnaires. Statistically significant and clinically relevant deterioration was seen on QLQ-H&N35 dry mouth and sticky saliva.

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Stereotactic radiotherapy boost after EBRT provides excellent local control for patients with NPC. Improved target delineation and dose homogeneity of radiation delivery for both EBRT and SRT is important to avoid long term complications. Better systemic therapies for distant control are needed.

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Our experience suggests that the CyberKnife is a suitable non- invasive radiation platform for delivering APBI with achievable normal tissue constraints. Al though the clinical out comes for this etrospective analysis are promising, the follow up is too limited and the number of treated patients is toosmalltopermitfirm conclusions.

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This paper is the among the first to report on using robotic SBRT in patients with real-time motion tracking for the treat ment of locally advanced cervical cancer in patients who are un able to under go brachytherapy. These preliminary results suggest that CyberKnife robotic SBRT is a safe and effective modality in the treatment of cervix cancer for those patients unable to undergo brachytherapy.

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In summary, we report here on the complete results of the first dose-escalation trial of SBRT for breast tumors. This protocol has a neoadjuvant breast-conserving chemoradiation approach for patients who are initially not suitable candidates for breastconserving surgery. With only 1 DLT reported, this study successfully demonstrated that SBRT could be safely combined with NACT.

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Multisession SRS with 18 Gy in 3 sessions results in excellent tumor control. The hearing preservation and nonauditory complication rates presented here are promising and comparable to those in other published series. Although hearing preservation rates are improved compared with earlier, higher-dose regimens, research is needed to further optimize the functional outcomes in our patients.

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The introduction of the CyberKnife extended the indication to 63 patients (30%) who could not have been treated by single-session radiosurgical techniques. The procedure proved to be safe. Clinical improvement seems to be more frequently observed with the CyberKnife than in our previous linear accelerator experience.

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