Publicaciones científicas y casos clínicos

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A phase II multi-institutional study assessing simultaneous in-field boost helical tomotherapy for 1-3 brain metastases

Whole Brain Radiation Therapy with Hippocampal Avoidance and Simultaneously Integrated Brain Metastases Boost

Composite tomotherapy plans achieved 3 objectives: homogeneous whole brain dose distribution equivalent to conventional WBRT; conformal hippocampal avoidance; radiosurgically-equivalent dose distributions to individual metastases.

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Helical tomotherapy simultaneous integrated boost provides a dosimetric advantage in the treatment of primary intracranial tumors

In summary, using the HT SIB technique provides a reduction in the radiation dose to the normal brain compared to using an SEQ technique. Although the clinical benefits of the use of the SIB technique are unknown, it has the potential to decrease the likelihood of adverse neurocognitive effects, particularly in patients with good performance status and life expectancies.

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Evaluation of image-guidance protocols in the treatment Of head and neck cancers

Residual setup errors reduce with increasing frequency of IG during the course of external-beam radiotherapy for head-and-neck cancer patients. The inability to reduce random setup errors for fractions that are not image guided results in notable residual setup errors.

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RapidArc, SmartArc and TomoHD compared with classical step and shoot and sliding window intensity modulated radiotherapy in an oropharyngeal cancer

Despite the limitations of a comparison such as used in the present study, we consider rotational IMRT techniques preferable to fixed gantry techniques due to faster fraction delivery times and better sparing of OARs without a higher integral dose.

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Treatment of nasopharyngeal carcinoma by tomotherapy: five-year experience

HT resulted in excellent long-term disease control and survival in heterogeneous NPC patients. Generally mild acute and late toxicity, with low rates of xerostomia, were obtained. Image-guided HT offers the ability to deliver conformal, OAR-sparing dose distributions to a wide variety of NPC patients with good long-term clinical outcomes.

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Intensity-modulated radiotherapy for nasopharyngeal carcinoma

The superior dosimetric outcome observed with HT appeared to translate into moderately improved clinical outcomes with respect to salivary sparing. Prospective trials are needed to validate this gain in the therapeutic ratio.

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Craniospinal Irradiation Using Helical Tomotherapy: Evaluation of Acute Toxicity and Dose Distribution

CSI using HT was feasible in pediatric as well as adult patients, and yielded promising outcome. Hematological toxicities were severest acute toxicities of CSI using HT, since all but 1 patient had received induction chemotherapy.

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Pediatric craniospinal axis irradiation with helicaltomotherapy

Craniospinal axis irradiation using helical tomotherapy yielded encouraging patient outcomes and acute toxicity profiles. Although large volumes of the lung received low radiation doses, no patient developed symptoms of ARP during the follow-up period.

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